Role of lipocalin 2 in intraventricular haemoglobin-induced brain injury
نویسندگان
چکیده
منابع مشابه
Role of lipocalin 2 in intraventricular haemoglobin-induced brain injury
OBJECTIVE Our recent studies have shown that blood components, including haemoglobin and iron, contribute to hydrocephalus development and brain injury after intraventricular haemorrhage (IVH). The current study investigated the role of lipocalin 2 (LCN2), a protein involved in iron handling, in the ventricular dilation and neuroinflammation caused by brain injury in a mouse model of IVH. DES...
متن کاملRole of Lipocalin-2 in Thrombin-Induced Brain Injury.
BACKGROUND AND PURPOSE Thrombin and lipocalin-2 (LCN2) contribute to intracerebral hemorrhage-induced brain injury. Thrombin-induced brain damage is partially through a thrombin receptor, protease-activated receptor-1. LCN2 is involved in cellular iron transport and neuroinflammation. This study investigated the role of LCN2 in thrombin-induced brain injury. METHODS There were 3 parts in this...
متن کاملRole of iron in brain injury after intraventricular hemorrhage.
BACKGROUND AND PURPOSE Intraventricular extension of hemorrhage is a predictor of poor outcome in intracerebral hemorrhage, and iron overload contributes to brain injury after intracerebral hemorrhage. The current study investigated the role of iron in ventricular dilatation and neuronal death in a rat model of intraventricular hemorrhage (IVH). METHODS There were 2 parts in this study. First...
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ژورنال
عنوان ژورنال: BMJ
سال: 2016
ISSN: 2059-8688,2059-8696
DOI: 10.1136/svn-2016-000009